May 13 , 2021
In December 2020, a large review study was published on the use of vitamin C hyperdoses in the treatment of respiratory infections, including Covid-19, and in the treatment of pneumonia and sepsis. It has been demonstrated that oral administration of vitamin C (2-8 g/day) can reduce the frequency and duration of respiratory infections, and intravenous administration (at doses of 6-24 g/day) reduces ICU (Intensive Care Unit) mortality and reduces treatment duration.
It has been known for a quarter of a century that critically ill patients, including those with sepsis and multiple organ failure, have very low blood levels of vitamin C. These patients are known to have higher vitamin C requirements, requiring grams (rather than milligrams) to normalize their levels, which is 20 to 30 times the accepted norm. Despite these findings, critically ill patients with sepsis continue to receive milligrams of the vitamin, which is insufficient to make up the deficiency.
The effect of vitamin C on survival has been most clearly demonstrated during the 4-day period of intravenous infusion. Pharmacokinetic studies showed that vitamin C levels returned to baseline low levels after the infusion was stopped. These data suggest that these patients need prolonged vitamin intake in the ICU and subsequent oral administration after discharge from the department.
A study conducted at the beginning of the "pandemic" was devoted to the problem of vitamin C deficiency. Researchers demonstrated that the majority of patients with Covid-19 in intensive care units have extremely low levels of vitamin C and D in their blood. Nevertheless, there has been no revision of the standard of care for Covid patients.
Low vitamin C and D levels in the body cause relative immunodeficiency and an increased risk of infectious disease. In effect, a temporary acquired immunodeficiency syndrome, i.e., AIDS (not to be confused with HIV) occurs.
Vitamin C is important not only for treatment, but also for prevention of respiratory disease. And a number of studies indicate that the therapeutic effect was insufficient even with "low" doses (up to 4 g/day) and the effect was only seen with 8 g/day.
Population studies show that people with high vitamin C intake have a lower risk of a number of chronic diseases, including heart disease, cancer, eye disease, and neurodegenerative diseases. We can speculate that the lack of vitamin C in treatment protocols for patients with coronavirus infection increases mortality from these diseases as well.
Vitamin C has a variety of biochemical functions, many of which are relevant to the pathophysiology of Covid-19. These include its antioxidant, anti-inflammatory, antithrombotic, and immunomodulatory properties.
That vitamin C plays a key role in the immune system is evidenced by the following facts:
1. The intracellular content of vitamin C in white blood cells is 50-100 times higher than its concentration in blood plasma. That is, this vitamin is a kind of "fuel" necessary for leukocyte function.
2. Vitamin C is involved in the migration of phagocytes (neutrophils and macrophages) to infection sites. Without the migration function, these blood cells are virtually useless.
3. Vitamin C stimulates the differentiation and proliferation of T lymphocytes. These blood cells are responsible for the development of the acquired immune response and are a major component of the antiviral defense.
Currently, there are more than 300 basic scientific and clinical studies confirming the need for high-dose vitamin C in severe infectious diseases. Nevertheless, the official recommendations from the Ministry of Health about coronavirus infection do not even mention vitamin C - neither for outpatient treatment, nor for the treatment of severe patients. The international recommendations from official medicine also do not contain vitamin C for some reason.
It may sound a bit conspiracy theory'ish, but for several decades people have been actively trying to discredit vitamin C. If you google it, the first thing you will come across is a lot of pseudoscientific articles about the dangers of hyperdoses of vitamin C. Probably someone doesn't like the fact that people can be treated with a cheap and effective remedy (besides, available from food). Vitamin C has been blamed for the risk of stone formation when consumed in high doses. This myth was debunked over 20 years ago, yet it is still alive today. For more details read the 1997 article "No contribution of ascorbic acid to renal calcium oxalate stones".
Let us know what is your take on vitamin C. Tag us on social media and let's discuss :)